SERPINE2

SERPINE2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4DY0, 4DY7
معین‌کننده‌ها
نام‌های دیگر	SERPINE2, GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, serpin family E member 2
شناسه‌های بیرونی	OMIM: 177010 MGI: 101780 HomoloGene: 21247 GeneCards: SERPINE2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	79,838,897 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • glycosaminoglycan binding; • peptidase inhibitor activity; • heparin binding; • serine-type endopeptidase inhibitor activity; • signaling receptor binding;
ترکیبات سلولی	• extracellular vesicle; • extrinsic component of external side of plasma membrane; • platelet alpha granule; • GO:0005578 بافت‌مانه برون‌یاخته‌ای; • سیتوزول; • تماس عصبی-ماهیچه‌ای; • extracellular region; • extracellular space; • collagen-containing extracellular matrix;
فرایند زیستی	• negative regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of cell growth; • seminal vesicle epithelium development; • secretory granule organization; • innervation; • mating plug formation; • جنین‌شناسی دستگاه عصبی مرکزی; • detection of mechanical stimulus involved in sensory perception; • multicellular organism development; • regulation of cell migration; • تقویت طولانی مدت; • regulation of timing of cell differentiation; • دگرگونی یاخته‌; • negative regulation of proteolysis; • GO:1903363 negative regulation of protein catabolic process; • negative regulation of plasminogen activation; • cerebellar granular layer morphogenesis; • negative regulation of cell population proliferation; • secretion by cell; • negative regulation of sodium ion transport; • negative regulation of smoothened signaling pathway; • negative regulation of protein processing; • positive regulation of astrocyte differentiation; • negative regulation of platelet activation; • response to wounding; • regulation of synaptic transmission, glutamatergic; • negative regulation of peptidase activity; • negative regulation of blood coagulation; • انعقاد خون; • negative regulation of platelet aggregation; • negative regulation of endopeptidase activity;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5270
	20720
	ENSG00000135919
	ENSMUSG00000026249
	P07093
	Q07235
	NM_001136530، NM_006216، NR_073116، XM_005246641، XM_017004330، XM_017004332 NM_001136528، NM_001136530، NM_006216، NR_073116، XM_005246641، XM_017004330، XM_017004332
	XM_006496459 NM_009255، XM_006496459
	NP_001130002، NP_006207، XP_005246698، XP_016859819، XP_016859821 NP_001130000، NP_001130002، NP_006207، XP_005246698، XP_016859819، XP_016859821
	XP_006496522 NP_033281، XP_006496522
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

نکسین مشتق شده از گلیا پروتئینی است که در انسان توسط ژن SERPINE2 کدگذاری می‌شود.^[۴]^[۵]

همچنین ببینید[ویرایش]

سرپین

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026249 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics. 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.
↑ "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".

جهت مطالعه[ویرایش]

Naldini L; Tamagnone L; Vigna E; et al. (1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor". EMBO J. 11 (13): 4825–33. doi:10.1002/j.1460-2075.1992.tb05588.x. PMC 556958. PMID 1334458.
Gloor S; Odink K; Guenther J; et al. (1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell. 47 (5): 687–93. doi:10.1016/0092-8674(86)90511-8. PMID 2877744. S2CID 35327577.
Sommer J; Gloor SM; Rovelli GF; et al. (1988). "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily". Biochemistry. 26 (20): 6407–10. doi:10.1021/bi00394a016. PMID 3427015.
Scott RW; Bergman BL; Bajpai A; et al. (1985). "Protease nexin. Properties and a modified purification procedure". J. Biol. Chem. 260 (11): 7029–34. doi:10.1016/S0021-9258(18)88883-4. PMID 3997857.
Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
Donovan FM, Vaughan PJ, Cunningham DD (1994). "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. doi:10.1016/S0021-9258(17)32540-1. PMID 8006028.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Nykjaer A; Conese M; Christensen EI; et al. (1997). "Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes". EMBO J. 16 (10): 2610–20. doi:10.1093/emboj/16.10.2610. PMC 1169872. PMID 9184208.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. doi:10.3748/wjg.v8.i2.213. PMC 4658353. PMID 11925594.
Grabham PW, Monard D, Gallimore PH, Grand RJ (1991). "Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin". The European Journal of Neuroscience. 3 (7): 663–668. doi:10.1111/j.1460-9568.1991.tb00852.x. PMID 12106474. S2CID 216379.
Crisp RJ, Knauer MF, Knauer DJ (2003). "Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV". J. Biol. Chem. 277 (49): 47285–91. doi:10.1074/jbc.M204813200. PMID 12356769.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Petrovic D; Milanez T; Kobal J; et al. (2003). "Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction". Acta Neurol. Scand. 108 (2): 109–13. doi:10.1034/j.1600-0404.2003.00126.x. PMID 12859287. S2CID 25978032.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim JA; Tran ND; Li Z; et al. (2006). "Brain endothelial hemostasis regulation by pericytes". J. Cereb. Blood Flow Metab. 26 (2): 209–17. doi:10.1038/sj.jcbfm.9600181. PMID 16015279.
Navaneetham D; Jin L; Pandey P; et al. (2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2". J. Biol. Chem. 280 (43): 36165–75. doi:10.1074/jbc.M504990200. PMID 16085935.
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

پیوند به بیرون[ویرایش]

پایگاه داده آنلاین MEROPS برای پپتیدازها و مهارکننده‌های آنها: I04.021
SERPINE2 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا سرفصل‌های

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026249 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_7665170-4] Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics. 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.

[entrez-5] "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".

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