USP8

USP8
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1WHB, 2A9U, 2GFO, 2GWF, 3N3K
معین‌کننده‌ها
نام‌های دیگر	USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
شناسه‌های بیرونی	OMIM: 603158 MGI: 1934029 HomoloGene: 3782 GeneCards: USP8
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	126,601,217 bp
هستی‌شناسی ژن
عملکرد ملکولی	• cysteine-type peptidase activity; • SH3 domain binding; • thiol-dependent deubiquitinase; • GO:0070122 peptidase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • cysteine-type endopeptidase activity; • hydrolase activity; • cadherin binding;
ترکیبات سلولی	• سیتوپلاسم; • اندوزوم; • membrane; • پوسته یاخته; • extrinsic component of endosome membrane; • midbody; • endosome membrane; • extrinsic component of plasma membrane; • هسته یاخته; • GO:0097483، GO:0097481 postsynaptic density; • dendritic spine; • early endosome; • سیتوزول; • glutamatergic synapse;
فرایند زیستی	• protein K48-linked deubiquitination; • ubiquitin-dependent protein catabolic process; • mitotic cytokinesis; • endosome organization; • پروتئین‌کافت; • protein K63-linked deubiquitination; • چرخه یاخته‌ای; • تکثیر سلولی; • protein deubiquitination; • cellular response to dexamethasone stimulus; • cellular response to nerve growth factor stimulus; • positive regulation of canonical Wnt signaling pathway; • Ras protein signal transduction; • regulation of protein stability; • regulation of protein localization; • regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9101
	84092
	ENSG00000138592
	ENSMUSG00000027363
	P40818
	Q80U87
	NM_001128611، NM_001283049، NM_005154 NM_001128610، NM_001128611، NM_001283049، NM_005154
	NM_019729، XM_011239857 NM_001252580، NM_019729، XM_011239857
	NP_001269978، NP_005145، XP_006720824، XP_006720825، XP_011520495، XP_016878207، XP_016878208، XP_016878209، XP_016878210، XP_016878211، XP_024305866 NP_001122082، NP_001269978، NP_005145، XP_006720824، XP_006720825، XP_011520495، XP_016878207، XP_016878208، XP_016878209، XP_016878210، XP_016878211، XP_024305866
	NP_062703، XP_011238159 NP_001239509، NP_062703، XP_011238159
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هیدرولاز ۸ ترمینال کربوکسیل یوبیکوئیتین آنزیمی است که در انسان توسط ژن USP8 کدگذاری می‌شود.^[۴]^[۵]^[۶]

فعل و انفعالات[ویرایش]

مشخص شده‌است که USP8 با RNF41^[۷] و STAM2 تعامل پروتئین-پروتئین دارد.^[۸]^[۹]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027363 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
↑ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
↑ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
↑ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
↑ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
↑ Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

جهت مطالعه[ویرایش]

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF (June 1998). "UBPY: a growth-regulated human ubiquitin isopeptidase". The EMBO Journal. 17 (12): 3241–50. doi:10.1093/emboj/17.12.3241. PMC 1170662. PMID 9628861.
Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.
Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, et al. (October 2001). "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1". The Journal of Biological Chemistry. 276 (42): 39448–54. doi:10.1074/jbc.M103454200. PMID 11500497.
Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, et al. (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nature Immunology. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020.
Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
Berruti G, Martegani E (January 2005). "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction. 72 (1): 14–21. doi:10.1095/biolreprod.104.030866. PMID 15342353.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Row PE, Prior IA, McCullough J, Clague MJ, Urbé S (May 2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation". The Journal of Biological Chemistry. 281 (18): 12618–24. doi:10.1074/jbc.M512615200. PMID 16520378.
Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M (August 2006). "A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes". Traffic. 7 (8): 1017–31. doi:10.1111/j.1600-0854.2006.00452.x. PMID 16771824.
Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (December 2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". The Journal of Biological Chemistry. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027363 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_12838346-4] Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.

[pmid_9582025-5] Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.

[entrez-6] "Entrez Gene: USP8 ubiquitin specific peptidase 8".

[pmid_15314180-7] Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

[pmid_13129930-8] Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.

[pmid_10982817-9] Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

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