گیرنده پلی‌پپتید بازدارنده گاستریک

GIPR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4HJ0, 2QKH
معین‌کننده‌ها
نام‌های دیگر	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
شناسه‌های بیرونی	OMIM: 137241 MGI: 1352753 HomoloGene: 20081 GeneCards: GIPR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	18,900,052 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • signal transducer activity; • gastric inhibitory peptide receptor activity; • transmembrane signaling receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • peptide hormone binding; • G protein-coupled peptide receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • پوسته یاخته;
فرایند زیستی	• response to fatty acid; • response to nutrient; • regulation of insulin secretion; • positive regulation of cytosolic calcium ion concentration; • response to glucose; • generation of precursor metabolites and energy; • activation of adenylate cyclase activity; • response to calcium ion; • cell surface receptor signaling pathway; • gastric inhibitory peptide signaling pathway; • response to axon injury; • desensitization of G protein-coupled receptor signaling pathway; • endocrine pancreas development; • GO:0072468 ورارسانی پیام; • positive regulation of insulin secretion; • G protein-coupled receptor signaling pathway; • positive regulation of cAMP-mediated signaling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2696
	381853
	ENSG00000010310
	ENSMUSG00000030406
	P48546
	Q0P543
	NM_001308418، XM_011526709، XM_011526710، XM_011526713، XM_011526715، XM_011526716، XM_047438599، XM_047438600، XM_047438601، XM_047438602، XM_047438603 NM_000164، NM_001308418، XM_011526709، XM_011526710، XM_011526713، XM_011526715، XM_011526716، XM_047438599، XM_047438600، XM_047438601، XM_047438602، XM_047438603
	XM_006540142، XM_006540143، XM_006540144، XM_006540145، XR_004934120، XR_004934121 NM_001080815، XM_006540142، XM_006540143، XM_006540144، XM_006540145، XR_004934120، XR_004934121
	NP_001295347، XP_011525011، XP_011525012، XP_011525013، XP_011525015، XP_011525016، XP_011525017، XP_011525018، XP_016882073، XP_016882074، XP_016882075، XP_016882076 NP_000155، NP_001295347، XP_011525011، XP_011525012، XP_011525013، XP_011525015، XP_011525016، XP_011525017، XP_011525018، XP_016882073، XP_016882074، XP_016882075، XP_016882076
	XP_006540205، XP_006540206، XP_006540207، XP_006540208 NP_001074284، XP_006540205، XP_006540206، XP_006540207، XP_006540208
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده پلی‌پپتید بازدارنده گاستریک (انگلیسی: Gastric inhibitory polypeptide receptor) که با نام گیرندهٔ پلی‌پپتید محرک انسولین وابسته به گلوکز یک پروتئین است که در انسان توسط ژن «GIPR» کدگذاری می‌شود.^[۴]^[۵]

این گیرنده یکی از اعضای خانوادهٔ بزرگ «گیرنده‌های جفت‌شونده با پروتئین جی» است.^[۶] و در سلول‌های بتای لوزالمعده یافت می‌شود.^[۷]^[۸]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030406 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: gastric inhibitory polypeptide receptor".
↑ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
↑ NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.
↑ "Gastrointestinal Hormones and Peptides". Archived from the original on 6 December 2007. Retrieved 2007-08-24.
↑ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

مشارکت‌کنندگان ویکی‌پدیا. «Gastric inhibitory polypeptide receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳۱ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر[ویرایش]

Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice". Horm. Metab. Res. 36 (11–12): 771–774. doi:10.1055/s-2004-826162. PMID 15655707.
Gremlich S; Porret A; Hani EH; et al. (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor". Diabetes. 44 (10): 1202–1208. doi:10.2337/diabetes.44.10.1202. PMID 7556958. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Volz A; Göke R; Lankat-Buttgereit B; et al. (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma". FEBS Lett. 373 (1): 23–29. doi:10.1016/0014-5793(95)01006-Z. PMID 7589426. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Usdin TB; Mezey E; Button DC; et al. (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain". Endocrinology. 133 (6): 2861–2870. doi:10.1210/en.133.6.2861. PMID 8243312. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Yamada Y; Hayami T; Nakamura K; et al. (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA". Genomics. 29 (3): 773–776. doi:10.1006/geno.1995.9937. PMID 8575774. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gallwitz B; Witt M; Morys-Wortmann C; et al. (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". Regul. Pept. 63 (1): 17–22. doi:10.1016/0167-0115(96)00019-5. PMID 8795084. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
N'Diaye N; Tremblay J; Hamet P; et al. (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome". J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. doi:10.1210/jc.83.8.2781. PMID 9709947. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling". Endocrinology. 141 (3): 947–952. doi:10.1210/en.141.3.947. PMID 10698169.
Bollag RJ; Zhong Q; Phillips P; et al. (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors". Endocrinology. 141 (3): 1228–1235. doi:10.1210/en.141.3.1228. PMID 10698200. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Baldacchino V; Oble S; Hamet P; et al. (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene". Endocr. Res. 28 (4): 577–577. doi:10.1081/ERC-120016843. PMID 12530665. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Antonini SR; N'Diaye N; Hamet P; et al. (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)". Endocr. Res. 28 (4): 755–756. doi:10.1081/ERC-120017003. PMID 12530694. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Manhart S; Hinke SA; McIntosh CH; et al. (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers". Biochemistry. 42 (10): 3081–3088. doi:10.1021/bi026868e. PMID 12627975. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo.00509.2002. PMID 12721154.
Grimwood J; Gordon LA; Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. doi:10.1038/nature02399. PMID 15057824. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hansotia T; Baggio LL; Delmeire D; et al. (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors". Diabetes. 53 (5): 1326–1335. doi:10.2337/diabetes.53.5.1326. PMID 15111503. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Baldacchino V; Oble S; Hamet P; et al. (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter". Endocr. Res. 30 (4): 805–806. doi:10.1081/ERC-200044046. PMID 15666829. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

پیوند به بیرون[ویرایش]

gastric inhibitory polypeptide receptor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030406 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: gastric inhibitory polypeptide receptor".

[pmid7490109-5] Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.

[NCBI-Gene-2696-6] NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.

[Helmenstine-7] "Gastrointestinal Hormones and Peptides". Archived from the original on 6 December 2007. Retrieved 2007-08-24.

[pmid12529935-8] Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

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